- Poor immunogenicity of proteins that are largely buried in the membrane.
- Low receptor density of membrane proteins in cell membranes.
- Difficulty to obtain the antigen in a pure form and in sufficient amounts.
- High degree of sequence homology between human and mouse genes.
- Antibodies against GPCR derived peptides rarely recognize native receptors.
M-fold Biotech offers GPCR antibody services to interested partners. The following collaboration options are offered:
Option 1. Antigens “For research only“, non-exclusive
For antibody generation by customer. Antibodies may not be used commercially. Terms:
- Customers provides GPCR sequence
- M-fold Biotech work includes:
- Cloning, expression
- Refolding, purification
- Reconstitution / formulation of antigen
- Deliverables:
- Antigen in different formulations (reconstituted, solubilized)
- Optional:
- Antibody characterization
- Affinity, Selectivity, Biological Function (cell-based assay)
- Service fee based on FTE will be charged
Option 2. Antigens "For research only", exclusive
M-fold Biotech will not deliver the same GPCR to other customers
- Conditions as above
- Annual exclusivity fee charged
Option 3. Antigens "For commercial use", exclusive
- Conditions as in Option 2.
- In addition clinical milestone and royalty payments will be charged
- Upgrade from option 2 to Option 3 possible at any time
We also offer custom antibody production together with our partners.
For all business requests, please contact us directly.
For more information on GPCR antigens and antibodies download the Factsheet GPCR Antibodies (pdf, 198 kB)
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